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Photobiomodulation (PBM) = Low-level Laser Therapy (LLLT)

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Resources on PBM: General

Research Journals

Currently around 5,000 papers regarding low-level laser therapy (LLLT) a.k.a. photobiomodulation (PBM) have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI)

Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.


Click on the interested topics below to view the related studies:

Research Studies published on NIH

Is LED-LLLT actually effective?

Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease

Arthritis: Photobiomodulation therapy on the inflammatory response induced by osteoarthritis

Brain damage: Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain?

Diabetic retinopathy: Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy

Heart disease: Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism

Shedding light on a new treatment for diabetic wound healing: a review on phototherapy

Eczema: Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema

Low-level laser therapy to treat fibromyalgia

Stroke: can infrared phototherapy effectively reach the human brain?

The Effects of 830 nm Light-Emitting Diode Therapy on Acute Herpes Zoster Ophthalmicus: A Pilot Study

Over-synthesis of melanin: Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo.

Pre-Conditioning with Low-Level Laser (Light) Therapy: Light Before the Storm

Depression: Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis

Neuroprotective Effects Against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton

Green light emitting diodes accelerate wound healing: characterization of the effect and its molecular basis in vitro and in vivo

Experiment report on NASA near-infrared ray and high pressure oxygen treatment

Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests

Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review

Complexion: Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

Wrinkle care: Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for Treating Wrinkles

Circulation, stroke, heart attack, spinal cord injury, and traumatic brain injury may soon be amenable to LLLT

The mechanism of light therapy by Dr. Saputo

Resources on PBM: Cancer

PBM Therapy for anticancer treatment side-effect relief

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Cancer Research Related

Photobiomodulation and Cancer: What Is the Truth?

Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients

Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients

‘‘Quantum Leap’’ in Photobiomodulation Therapy Ushers in a New Generation of Light-Based Treatments for Cancer and Other Complex Diseases

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Recommendations

Photobiomodulation Therapy in the Treatment of Oral Mucositis, Dysgeusia and Oral Dryness as Side-Effects of Head and Neck Radiotherapy in a Cancer Patient: A Case Report

Photobiomodulation is associated with a decrease in cell viability and migration in oral squamous cell carcinoma

Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema

Photobiomodulation therapy in the management of oral mucositis: search for the optimal clinical treatment parameters

cDNA microarray analysis of human keratinocytes cells of patients submitted to chemoradiotherapy and oral photobiomodulation therapy

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

Biological effects and medical applications of infrared radiation

Low level laser therapy for the management of breast cancer-related lymphedema: A randomized controlled feasibility study

Photobiomodulation of breast and cervical cancer stem cells using low-intensity laser irradiation

Photobiomodulation therapy in breast cancer-related lymphedema: a randomized placebo-controlled trial

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles

A novel Met-IR-782 near-infrared probe for fluorescent imaging-guided photothermal therapy in breast cancer

Photobiomodulation therapy for the management of radiation-induced dermatitis

Low level laser therapy for the management of breast cancer-related lymphedema: A randomized controlled feasibility study

Laser photobiomodulation of pro-inflammatory mediators on Walker Tumor 256 induced rats

Recources on PBM: Brain

PBM therapy for Dementia

PBM Therapy for the brain damages (TBI)

Brain disease related

Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition

Neuroprotective effect of a new photobiomodulation technique against Aβ 25-35 peptide-induced toxicity in mice

Shining light on the head: Photobiomodulation for brain disorders

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Remote tissue conditioning is neuroprotective against MPTP insult in mice

Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury

Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury

Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

No evidence for toxicity after long-term photobiomodulation in normal non-human primates

Photobiomodulation and the brain: a new paradigm

Photobiomodulation for traumatic brain injury and stroke

Photobiomodulation Therapy Attenuates Hypoxic-ischemic Injury in a Neonatal Rat Model

Brain Photobiomodulation Therapy: A Narrative Review

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells

Effects of Near-Infrared Light on Cerebral Bioenergetics Measured with Phosphorus Magnetic Resonance Spectroscopy

Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain

Repeated transcranial low-level laser therapy for traumatic brain injury in mice: biphasic dose response and long-term treatment outcome

Beneficial neurocognitive effects of transcranial laser in older adults

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury

Photobiomodulation-induced changes in a monkey model of Parkinson's disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum

Resources on PBM: muscle/joint pain

New Hope for the patients with ulcers: Nitric Oxide (NO) synthesis through PBM therapy

by Dr. Thomas Burke

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Peripheral neuropathy and diabetes

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial

Effects of photobiomodulation on experimental models of peripheral nerve injury

Symptomatic reversal of peripheral neuropathy in patients with diabetes

Reversal of diabetic peripheral neuropathy and new wound incidence: the role of MIRE

Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy with monochromatic near-infrared treatment

The restorative effects of pulsed infrared light therapy on significant loss of peripheral protective sensation in patients with long-term type 1 and type 2 diabetes mellitus

Reversal of diabetic peripheral neuropathy with phototherapy (MIRE) decreases falls and the fear of falling and improves activities of daily living in seniors

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy

Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers

New insights into the treatment of non-healing diabetic foot ulcers

Photobiomodulation therapy in neuroischaemic diabetic foot ulcers: a novel method of limb salvage

Mitochondrial dynamics (fission and fusion) and collagen production in a rat model of diabetic wound healing treated by photobiomodulation

Cell Adhesion Molecules Are Mediated by Photobiomodulation at 660 nm in Diabetic Wounded Fibroblast Cells

The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats

Resources on PBM: Exercise

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Pre-/Post-exercise

Photobiomodulation in human muscle tissue: an advantage in sports performance?

Low Level Laser Therapy (LLLT) Almost Doubles Muscle Gains & Ramps Up Concentric & Eccentric Peak Torque Development During 8-Week Eccentric Training Program

Pre-Exercise Infrared Photobiomodulation Therapy (810 nm) in Skeletal Muscle Performance and Postexercise Recovery in Humans: What Is the Optimal Power Output?

Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better?

Protection of Skeletal Muscles from Ischemic Injury: Low-Level Laser Therapy Increases Antioxidant Activity

Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-kappaB signaling pathway in traumatized muscle

Identifying Dosage Effect of Light-Emitting Diode Therapy on Muscular Fatigue in Quadriceps

Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training

Low-level phototherapy to improve exercise capacity and muscle performance

Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review

Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test

Effect of low-level laser therapy (808 nm) on skeletal muscle after endurance exercise training in rats

830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study

The Future of Medicine: Boost Your Health, Mental Abilities and Athletic Ability with Light. “Photobiomodulation”

Photobiomodulation therapy as a tool to prevent hamstring strain injuries by reducing soccer-induced fatigue on hamstring muscles

Resources on MHIT: Parkinson's and brain diseases

Molecular Hydrogen Inhalation Therapy

Started from Dr. Shigeo Ohta’s (Nippon Medical School) clinical trial on oxidative effect of hydrogen, multiple papers on hydrogen treatment have been published, and hydrogen has been drawing a lot of attention by numerous people.


As a result for the past 10 years, ‘hydrogen water generator’ has been popular among people, and lots of hydrogen water related products, such as hydrogen water generator and tumblers are being sold. However, most scientists has been raising a question in hydrogen water.


According to the statement from Ministry of Food and Drug Safety, hydrogen in hydrogen water generator is either not present, or barely present. Not only it is barely present, but it evaporates once it is exposed to oxygen of certain temperature, or it doesn’t get absorbed into the body. Thus, at last recent news reported that drinking hydrogen generated water is no different than drinking ‘normal’ water. This shows a theory that separated hydrogen gas does not dissolve into water on its own. 

Moreover, once water containing trace of hydrogen is exposed to oxygen or the temperature increases, hydrogen within the water immediately evaporates. As this scientific knowledge and the fact that most of Dr. Shigeo Ohta’s and others’(Nippon Medical School) clinical trials used hydrogen gas came to be acknowledged, Hydrogen inhalation therapy has been suddenly drawn into attention.

Hydrogen is a powerful antioxidant

The effect of hydrogen inhalation

The effect of Hydrogen

by Dr. Garth Nicolson

Testimonial: a diabetic using hydrogen inhalation therapy

Moreover, once water containing trace of hydrogen is exposed to oxygen or the temperature increases, hydrogen within the water immediately evaporates. As this scientific knowledge and the fact that most of Dr. Shigeo Ohta’s and others’(Nippon Medical School) clinical trials used hydrogen gas came to be acknowledged, Hydrogen inhalation therapy has been suddenly drawn into attention.


There are approximately 600 research papers released on its effect on the symptoms of relieving chronic disease including anti-inflammatory, antioxidant, anti-apoptosis effects; reducing oxidative stress, inflammatory response, and multiple sepsis damage; as well as reproducing organisms that protect against acute peritonitis. In addition, many successful clinical trial cases have been reported.

Parkinson's and Brain diseases

Parkinson’s is a nerve disease that is caused by the lack of dopamine in the brain. Major symptoms include shaking of hands and feet, slower movement, muscle stiffness and it might also develop dementia as complication. Symptoms arise the most around the age after 40s~50s, and it is categorized as an incurable disease.



Researches have been happening in Japan and USA to study whether molecular hydrogen, a strong anti-oxidant, has the ability to suppress progression of Parkinson’s and other brain diseases.
This page organizes some important research papers on the relationship of hydrogen and Parkinson’s/brain diseases. (Source: https://www.ncbi.nlm.nih.gov) We hope that it will help Parkinson’s/brain disease patients and their families.

Resources on MHIT: Cancer

Balanced Immunity is the key factor of healthy body

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Cancer

Kidney Related Diseases

Lung diseases

Other diseases

Preventive

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